BDBM50545945 CHEMBL4777342

SMILES Cn1cc(NC(=O)c2cnn3cccnc23)c(n1)-c1cc(Cl)ccc1OC(F)F

InChI Key InChIKey=CJXPNZXEEPSZHK-UHFFFAOYSA-N

Data  2 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50545945   

TargetNon-receptor tyrosine-protein kinase TYK2/Tyrosine-protein kinase JAK1/Tyrosine-protein kinase JAK2/Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Genentech

Curated by ChEMBL

LigandBDBM50545945(CHEMBL4777342)Copy SMILESCopy InChI

Affinity DataIC50:  4.70nMAssay Description:Inhibition of JAK in human BEAS-2B cells assessed as reduction in IL13-induced STAT6 phosphorylation incubated for 1 hr followed by IL13 addition and...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
antibodypediaantibodypediaantibodypediaantibodypediaGoogleScholar

Ligand InfoPC cidPC sidPDB

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI